Treating Parkinson disease in certain patients. Comtan must be taken along with levodopa/carbidopa.
Comtan is a catechol-O-methyltransferase (COMT) inhibitor. It works by increasing the levels of levodopa/carbidopa in the brain, enhancing its effectiveness.
Do not use Comtan if:
you are allergic to any ingredient in Comtan
Contact your doctor or health care provider right away if any of these apply to you.
Before using Comtan:
Some medical conditions may interact with Comtan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver disease, mental or mood problems, sleep problems, or a history of a severe muscle problem called rhabdomyolysis
- if you have taken certain monoamine oxidase inhibitors (MAOIs) (eg, phenelzine, tranylcypromine) within the past 14 days
How to use Comtan:
Use Comtan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Comtan should be given each time a dose of levodopa/carbidopa is given.
If you miss a dose of Comtan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Comtan.
Important safety information:
Comtan may cause dizziness and drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Comtan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Comtan may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of dizziness, light-headedness, or weakness.
Possible side effects of Comtan:
- Absence of or decrease in body movements
- increase in body movements
- seeing, hearing, or feeling things that are not there
- uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
- Cough or hoarseness
- fever or chills
- lower back or side pain
- painful or difficult urination
- muscle cramps
- shortness of breath
- unusual tiredness or weakness
- Abdominal or stomach pain
- Acid or sour stomach
- burning feeling in the chest or stomach
- difficult or labored breathing
- dry mouth
- loss of strength or energy
- muscle pain or weakness
- passing gas
- sleepiness or unusual drowsiness
- small, red spots on the skin
- stomach discomfort, upset, or tenderness
- sweating increased
- tightness in the chest
- trouble sleeping
- unusual or unpleasant (after) taste
- unusual weak feeling
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